进展快过马斯克，中国独创脑机接口为何选择在上海产业化

“上周五，第三例无线微创脑机接口植入者小董从华山医院顺利出院，信号非常好！”

11月17日，清华大学生物医学工程学院洪波教授在2024中国医药工业发展大会和上海国际生物医药产业周“张江协同聚力新质生产力发展论坛”上透露，他和学生联手研发的无线微创脑机接口产品NEO顺利进入国家药监局创新医疗器械特别审批“绿色通道”，后续将在上海实现产业化。

全力打造世界级生物医药产业集群，上海正以“全链条赋能”，在生物医药领域培育新质生产力。无论是脑机接口，还是人工智能（AI）制药，都需要多学科交叉、多方资源汇聚。不少专家认为，随着生命科学与信息科学加速交叉融合，尤其在AI的赋能下，新技术新产品为社会发展带来的增量将远超以往。

选择上海，NEO打开产业化之路

“我们做脑机接口，不是为了跟马斯克比拼赛跑，而是要真切解决患者的病痛。”过去一段时间，洪波教授承受了极大压力，因为提到脑机接口，大家就会将NEO与美国神经连接公司（Neuralink）作比较。

独创半侵入式脑机接口，是因为从事神经工程、脑机接口20多年的研究经验告诉洪波，要紧扣“上临床”这个关键点——在创伤小、信号清晰持久之间，找到一个最佳平衡点。正是在这一思路下，他带领团队研发的NEO比Neuralink更早植入了患者大脑。

如今，只有硬币大小的NEO在首例植入患者的颅骨下、脑硬膜外，已实现了在体12个月安全有效工作。洪波提到，首例患者不仅能够借助脑机接口实现脑控抓握，自主喝水吃饭，准确率超过90%；而且在上肢运动和感觉功能康复方面取得显著进展，上肢动作评估量表（ARAT）提升27分，脊髓损伤量表（ASIA）提升13分。

随着Neuralink在首位植入者脑内出现芯片电极大量移位，无法正常接收信号等问题，洪波主导的半侵入式方案的优越性开始显现。

“我非常感谢我的学生，NEO的产业化全靠他们在上海创办的博睿康公司。”洪波透露，NEO即将完成从1.0到2.0版的升级，将于明年开始大规模临床试验，而上海将成为它落地发展的首选地。

一项医疗技术要从实验室走向临床、进入市场，需要从材料、性能、工艺等多方面不断完善。在洪波看来，博睿康就在张江，这里集聚着大量生物医药企业以及各类高技术创新公司，“这样的创新生态必定有利于NEO的产业化发展”。

最近，博睿康刚完成了D轮融资，又与华山医院神经外科合作完成了NEO的全国第三例、上海首例临床试验植入手术。“华山神外的医生只用了一个半小时，就完成了定位极为精准的植入手术。”

目前，他们正在通过“绿色通道”和器审中心沟通大规模临床试验（III期）的入组标准和例数，计划明年完成多中心III期临床试验。洪波相信，在全链条赋能的产业生态下，立足上海发展脑机接口，有望事半功倍。

"Last Friday, Xiao Dong, the third patient with wireless minimally invasive brain computer interface implant, was discharged from Huashan Hospital successfully, and the signal is very good!"

On November 17, professor Hong Bo of the School of Biomedical Engineering of Tsinghua University revealed at the 2024 China Pharmaceutical industry Development Conference and the Shanghai International Biomedical Industry Week "Zhangjiang Collaborative Poly New quality Productivity Development Forum" that the wireless minimally invasive brain-computer interface product NEO jointly developed by him and his students successfully entered the "green channel" for special approval of innovative medical devices by the State Food and Drug Administration. It will be followed by industrialization in Shanghai.

Striving to build a world-class biomedical industrial cluster, Shanghai is cultivating new quality productivity in the biomedical field with "full chain empowerment". Whether it is brain-computer interface or artificial intelligence (AI) pharmaceutical, it requires multidisciplinary and multi-party resources. Many experts believe that with the accelerated cross-integration of life science and information science, especially under the empowerment of AI, the increment brought by new technologies and new products to social development will be far greater than in the past.

Choosing Shanghai, NEO opens the road to industrialization

"We're not building brain-computer interfaces to compete with Musk in a race, but to actually solve the patient's pain." In the past, Professor Hong Bo has been under a lot of pressure, because when it comes to brain-computer interfaces, people will compare NEO to the US company Neuralink.

The original semi-invasive brain computer interface, because engaged in neural engineering, brain computer interface more than 20 years of research experience told Hong Bo, to closely adhere to the "clinical" the key point - between small trauma, clear and durable signal, to find an optimal balance. It is in this line of thinking that NEO, which he led the team to develop, was implanted in patients' brains earlier than Neuralink.

Today, NEO, which is only the size of a coin, has been safely and effectively working in the body for 12 months after being implanted under the skull of the first patient, the epidural of the brain. Hong Bo mentioned that the first patient can not only realize brain-controlled grasping with the help of brain-computer interface, but also drink and eat independently, with an accuracy rate of more than 90%; In addition, significant progress was made in the rehabilitation of upper limb motor and sensory function, with an improvement of 27 points on the Upper Limb Motor Assessment Scale (ARAT) and 13 points on the Spinal Cord injury Scale (ASIA).

With Neuralink having a large number of chip electrodes displaced in the brain of the first implant recipient and unable to receive signals normally, the advantages of the semi-invasive scheme led by Hong Bo began to emerge.

"I am very grateful to my students for the industrialization of NEO thanks to the company they founded in Shanghai." Hong Bo revealed that NEO is about to complete the upgrade from version 1.0 to 2.0, and will start large-scale clinical trials next year, and Shanghai will be the first choice for its landing development.

A medical technology from the laboratory to clinical, to enter the market, need from the material, performance, technology and other aspects of continuous improvement. In Hong Bo's view, Boricom is located in Zhangjiang, where a large number of biomedical enterprises and various high-tech innovation companies gather, "such an innovation ecology will certainly be conducive to the industrialization of NEO."

Recently, Briacon has just completed the D round of financing, and cooperated with the Neurosurgery department of Huashan Hospital to complete the third case of NEO in China and the first clinical trial implantation surgery in Shanghai. "The doctors outside Huashan completed the implantation surgery with extremely precise positioning in only one and a half hours."

At present, they are communicating the enrollment criteria and number of cases for large-scale clinical trials (Phase III) through the "green channel" and the organ review center, and plan to complete the multi-center phase III clinical trial next year. Hong Bo believes that under the industrial ecology of full chain empowerment, the development of brain-computer interface based on Shanghai is expected to get twice the result with half the effort.

  1.Striving to build a world-class biomedical industrial cluster, Shanghai is cultivating new quality productivity in the biomedical field with "full chain empowerment"

句子成分分析：(划分说明)  提示：框中标识可点击

[Striving to build a world-class biomedical industrial cluster], Shanghai is cultivating new quality productivity [in the biomedical field] [with "full chain empowerment]"

句子语法结构详解：

* Striving 为现在分词。现在分词短语作句子状语。
* to build 为不定式，作状语。
* cultivating 为谓语，采用现在进行时。
* is 为助动词。the 为定冠词。a 为不定冠词。

相关语法知识:
   现在分词
   不定式
   时态
   助动词

句子相关词汇解释：

Phrase:

Vocabulary:

句子语法错误检查：

(未发现错误)

句子相关学习点：

 现在分词作状语和不定式作状语的区别
 try to do sth 和 try doing sth 的区别

  2. Whether it is brain-computer interface or artificial intelligence (AI) pharmaceutical, it requires multidisciplinary and multi-party resources.

句子成分分析：(划分说明)  提示：框中标识可点击

Whether it is brain-computer interface or artificial intelligence (AI) pharmaceutical, || it requires multidisciplinary and multi-party resources.

句子语法结构详解：

* whether 引导让步状语从句。
* is 为系动词作谓语，采用一般现在时。
* 第2个 it 开头为陈述句。
* requires 为谓语，采用一般现在时。动词采用第三人称单数形式。

相关语法知识:
   状语从句
   系动词
   时态
   并列连词
   动词的第三人称单数形式

句子相关词汇解释：

Phrase:

Vocabulary:

句子语法错误检查：

(未发现错误)

句子相关学习点：

  3.Many experts believe that with the accelerated cross-integration of life science and information science, especially under the empowerment of AI, the increment brought by new technologies and new products to social development will be far greater than in the past.

句子成分分析：(划分说明)  提示：框中标识可点击

Many experts believe | that [with the accelerated cross-integration (of life science and information science)], [especially under the empowerment (of AI)], the increment brought [by new technologies and new products] [to social development] will be far greater || than in the past.

句子语法结构详解：

(brought 为 bring 的过去分词。greater 为 great 的比较级形式)

* believe 为谓语，采用一般现在时。
* that 为连词，引导宾语从句。
* accelerated 为过去分词作定语
* brought 为过去分词，作后置定语。
* be 为系动词作谓语，采用一般将来时。
* great 为形容词作表语。
* than 为连词，引导比较状语从句。句子有省略。
* will 为情态动词。the 为定冠词。

相关语法知识:
   时态
   宾语从句
   过去分词
   并列连词
   系动词
   形容词的比较级和最高级
   表语
   省略句
   状语从句
   many, much 的用法
   情态动词

句子相关词汇解释：

Phrase:

Vocabulary:

句子语法错误检查：

Many experts believe that with the accelerated cross-integration of life science and information science, especially under the empowerment of AI, the increment brought by new technologies and new products to social development will be far greater than in the past.

 不可数名词不能用复数形式。 (详解)

句子相关学习点：

 below 和 under 的区别

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